Yes, the Amtrak Missouri River Runner runs daily between the two cities.

How long is the drive?

It is approximately 2 hours via US-50 and I-44.

It has areas with high crime; stick to the tourist-friendly downtown and Forest Park areas.

What is the best way to travel?

The train is more relaxing, while driving offers more flexibility.

Are there direct routes?

Yes, both the train and the highway provide direct routes.

Jefferson City

St. Louis

Train Driving

Jefferson City to St. Louis

Updated: 28 May 2026

The journey from Jefferson City to St. Louis is a short, scenic trip across Missouri. You can take the Amtrak Missouri River Runner train, which offers a relaxing ride along the river, or drive via US-50 and I-44. The train ride takes about 2 hours and 30 minutes, while driving takes approximately 2 hours. This route connects the state capital to the vibrant cultural hub of St. Louis.

Total Distance: Driving distance 200 km, straight-line air distance 185 km.

Fastest Way

Driving, typically taking 2 hours depending on traffic.

Cheapest Way

Amtrak train, starting at 25 dollars if booked in advance.

Compare Jefferson City to St. Louis Routes

	Train Direct	Driving Direct
Duration	2 hours 30 mins	2 hours
Avg Price	25-40 USD	20-30 USD (fuel)
Operator	Amtrak	N/A
Route	Jefferson City Station to St. Louis Gateway Station	US-50 E to I-44 E
Tip	The train offers beautiful views of the Missouri River that you cannot see from the highway.	Driving gives you the flexibility to stop in small towns along the way.

Travel Tips

Train Travel
Book your Amtrak tickets early to get the best prices.
Driving
Be prepared for traffic when entering St. Louis during rush hour.
Walking
Downtown St. Louis is walkable, but you will need a car for other areas.
Dining
Try the local St. Louis-style pizza and toasted ravioli.
Parking
Use parking garages in downtown St. Louis for convenience and safety.

Safety Tips

General Safety
St. Louis has areas with high crime; stay in well-traveled tourist zones.
Night Safety
Avoid walking alone at night, especially in less populated areas.
Driving
Keep your car doors locked and do not leave valuables visible.
Emergency
Keep emergency numbers saved and stay aware of your surroundings.