The journey from Jefferson to Knoxville covers about 180 miles. Driving is the most practical mode, taking roughly 3 hours via I-75 North. You will pass through the scenic mountains of East Tennessee. Knoxville is a vibrant city known for its university, historic downtown, and proximity to the Great Smoky Mountains.
Total Distance: 290 km driving, 250 km air distance.
I-75 is a major artery with heavy truck traffic.
Autumn for the beautiful foliage.