Driving
Lake St Louis to Des Moines
Updated: 28 May 2026
The drive from Lake St Louis to Des Moines covers 500 kilometers, primarily using US-61 North and Interstate 80 West. You will travel through the rolling farmland of Missouri and Iowa. The trip takes about 5 hours. Des Moines is the capital of Iowa and offers a variety of cultural and outdoor attractions.
Total Distance: 500 km driving distance; 440 km straight-line air distance.
Fastest Way
Driving via US-61 and I-80 is the fastest, taking 5 hours.
Cheapest Way
Driving your own vehicle is the most economical option.
Compare Lake St Louis to Des Moines Routes
Driving
Direct
Duration
5 hours
Avg Price
60-80 USD
Operator
Personal Vehicle
Route
US-61 North to I-80 West through Davenport.
I-80 is a major trucking route; expect heavy traffic.
Travel Tips
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TrafficAvoid I-80 rush hour near Des Moines.
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DiningTry a local pork tenderloin sandwich.
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ParkingUse downtown parking garages for easy access.
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NavigationUse a GPS to navigate the city's highway system.
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WeatherBe prepared for high winds on the open plains.
Safety Tips
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SpeedingWatch for speed limit changes in small towns.
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WeatherBe alert for severe storms in the spring and summer.
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VehicleCheck your tire pressure before the long drive.
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EmergencyKeep a roadside kit in your vehicle.
People Also Ask
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Is there a train?No, there is no direct passenger train service.
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How long is the drive?The drive is approximately 5 hours.
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Are there tolls?No, this route is toll-free.
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What is the best route?US-61 North to I-80 West is the most direct route.
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Is Des Moines safe?Yes, it is generally safe for tourists in the downtown and cultural areas.
Quick Info
- From Lake St Louis, Missouri, United States
- To Des Moines, Iowa, United States
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Modes
Best Time to Travel
August for the Iowa State Fair or May for pleasant weather.
Things to Do in Des Moines
1
Iowa State Capitol
Tour the beautiful gold-domed capitol building.
2
Greater Des Moines Botanical Garden
Explore the stunning conservatory and outdoor gardens.
3
Des Moines Art Center
View a diverse collection of modern and contemporary art.
4
Pappajohn Sculpture Park
Walk through the park featuring world-class sculptures.
Tags
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