Is Des Moines walkable?

Downtown Des Moines is very walkable.

What is the best airport?

Des Moines International Airport (DSM) is the primary hub.

Are there direct flights?

No, all flights from TPA require a connection.

How long is the drive?

It takes about 21 hours of driving time.

Yes, I-35 is a major, well-maintained interstate.

Largo

Des Moines

Flight Driving

Largo to Des Moines

Updated: 28 May 2026

Traveling from Largo to Des Moines involves crossing the heart of the United States. You can fly from Tampa International Airport to Des Moines International Airport with one stop. Driving takes you through the Southeast and into the Midwest via I-75 and I-35. The total driving distance is roughly 2,200 kilometers. Expect a travel time of about 21 hours by car. This route offers a transition from coastal Florida to the rolling agricultural landscapes of Iowa.

Total Distance: Driving distance 2,220 km, straight-line air distance 1,850 km.

Fastest Way

Flying is the fastest, taking under 6 hours.

Cheapest Way

Driving is the most cost-effective for families.

Compare Largo to Des Moines Routes

	Flight Connecting	Driving Direct
Duration	5 hours 30 mins	21 hours
Avg Price	$350-$700	$300-$450 in fuel
Operator	American Airlines	Personal Vehicle
Route	TPA to DSM via CLT or ORD.	I-75 N, I-24 W, I-57 N, I-35 N.
Tip	Check flights into DSM early to avoid high last-minute prices.	Use cruise control on I-35 to maintain fuel efficiency.

Travel Tips

Airport Parking
Use the economy lot at TPA to save on parking fees.
Route Planning
Use GPS apps to monitor traffic around major cities like Atlanta.
Hydration
Drink plenty of water during the long drive.
Hotel Booking
Book hotels in advance if traveling during peak summer months.
Snacks
Pack healthy snacks to avoid frequent fast-food stops.