Flight
Driving
Lexington to St. Louis
Updated: 31 May 2026
The journey from Lexington, South Carolina to St. Louis, Missouri covers approximately 850 miles. Flying from Columbia Metropolitan Airport (CAE) to St. Louis Lambert International Airport (STL) is the most efficient method, usually requiring a connection. Driving takes roughly 13 hours via I-26 W and I-64 W. You will cross the Appalachian Mountains and the Ohio River Valley. This route takes you from the humid South to the heart of the Midwest.
Total Distance: 1,370 km driving; 1,150 km air distance.
Fastest Way
Flying from CAE to STL takes approximately 5 hours including a layover.
Cheapest Way
Driving is the most cost-effective option for groups of two or more.
Compare Lexington to St. Louis Routes
|
Connecting
|
Direct
|
|
|---|---|---|
| Duration | 5 hours | 13 hours |
| Avg Price | $250-$500 | $200 in fuel |
| Operator | American Airlines | Personal Vehicle |
| Route | CAE to CLT to STL | I-26 W to I-64 W |
| Tip | Book flights arriving at STL to utilize the MetroLink train into downtown. | Plan for heavy traffic when entering the St. Louis metropolitan area. |
Travel Tips
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Public TransitThe MetroLink light rail is an efficient way to get from the airport to downtown.
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DiningTry the local St. Louis-style pizza and toasted ravioli.
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WalkingDowntown St. Louis is walkable, but be prepared for some hills.
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BookingBook popular attractions like the Gateway Arch tram online to avoid long lines.
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WeatherSt. Louis weather can be unpredictable; check the forecast before you go.
Safety Tips
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Urban AwarenessStay alert in downtown areas at night, especially near the entertainment districts.
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WeatherBe cautious of severe thunderstorms during the spring and summer months.
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Emergency PrepKeep a basic emergency kit in your car if you are driving across the mountains.
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NavigationUse real-time traffic apps to navigate around freeway accidents.
People Also Ask
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Is there a train to St. Louis?Amtrak's Texas Eagle and Lincoln Service both serve St. Louis's Gateway Station.
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What is the best airport?St. Louis Lambert International Airport (STL) is the only major airport serving the region.
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Do I need a car?Yes, St. Louis is a car-centric city and public transit is limited for tourists.
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How long is the flight?A flight with a connection typically takes 4 to 6 hours.
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Is St. Louis expensive?No, St. Louis is generally more affordable than many other major US cities.
Quick Info
- From Lexington, South Carolina, United States
- To St. Louis, Missouri, United States
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Modes
Best Time to Travel
May to June or September to October for mild weather.
Things to Do in St. Louis
1
Gateway Arch
Visit this iconic monument and take the tram to the top for panoramic views of the city and the Mississippi River.
2
Forest Park
Explore this massive urban park, which is larger than Central Park and home to the St. Louis Zoo and Art Museum.
3
City Museum
Experience this unique, interactive museum built from repurposed industrial materials; it is fun for all ages.
4
Anheuser-Busch Brewery
Take a tour of this historic brewery to learn about the history of beer in St. Louis.
Tags
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