How far is Jacksonville?

It is approximately 260 miles from Lexington, SC.

Amtrak serves Jacksonville, but it requires a transfer in Savannah or other hubs.

What is the best route?

I-26 East to I-95 South is the most direct path.

There are no major tolls on the direct route from Lexington to Jacksonville.

Yes, it is a well-traveled interstate route with plenty of services.

Lexington

Jacksonville

Driving

Lexington to Jacksonville

Updated: 31 May 2026

Traveling from Lexington to Jacksonville is a straightforward 260-mile drive. You will primarily use I-26 East to connect with I-95 South. This route takes you through the heart of the South Carolina Lowcountry and into Northeast Florida. It is a popular route for weekend getaways to the Atlantic coast. Expect to spend about 4 hours on the road under normal traffic conditions.

Total Distance: 420 km driving distance; 385 km straight-line air distance.

Fastest Way

Driving is the fastest method as there are no direct commercial flights from Columbia to Jacksonville.

Cheapest Way

Driving your own vehicle is the most cost-effective method for this distance.

Compare Lexington to Jacksonville Routes

Driving

Direct

Duration

4 hours

Avg Price

$40-$60 in fuel

Operator

Personal Vehicle

Route

I-26 E to I-95 S

Stop in Savannah, GA for a quick lunch to break up the drive.

Travel Tips

Route Planning
Check for construction on I-95 near the South Carolina-Georgia border.
Rest Stops
The South Carolina Welcome Center on I-95 is a great place to stretch your legs.
Dining
Try the local seafood in the historic district of Jacksonville.
Navigation
Download offline maps as cell service can be spotty in rural parts of the Lowcountry.
Parking
Downtown Jacksonville offers several public parking garages with reasonable daily rates.

Safety Tips

Speed Limits
Strictly observe speed limits in small towns along the route to avoid fines.
Wildlife
Be cautious of deer crossing the road, especially during dawn and dusk.
Weather
Check the forecast for coastal fog which can affect visibility on I-95.
Vehicle Prep
Ensure your spare tire is inflated before starting your journey.