The drive from Lexington to Tampa covers about 550 miles. You will typically take I-26 East to I-95 South, then transition to I-75 South in Florida. This route takes you through the scenic landscapes of South Carolina, Georgia, and Florida. Expect a travel time of approximately 8 to 9 hours depending on traffic in major cities like Jacksonville. It is a popular route for those seeking the Gulf Coast beaches.
Total Distance: 885 km driving distance; 750 km straight-line air distance.
Take the I-75 bypass around Jacksonville to save time.
November to April for comfortable weather and avoiding the peak summer heat.