The drive from Louisa to Baltimore is approximately 480 miles and takes about 8 hours. You will travel east on I-64, then north through Maryland via I-70. This route takes you through the scenic Appalachian region and into the Mid-Atlantic. Baltimore is a major port city with a historic harbor district. Expect heavy traffic as you approach the Baltimore-Washington corridor.
Total Distance: 772 km driving distance, 600 km straight-line air distance.
The Baltimore Harbor Tunnel has tolls; ensure you have an E-ZPass.
Late spring or early fall for pleasant harbor weather.