The journey from Louisa, Kentucky to Charleston, South Carolina is approximately 550 miles. You will travel south through West Virginia and North Carolina on I-77, then take I-26 East directly to the coast. This route offers a beautiful drive through the Blue Ridge Mountains before descending into the Lowcountry. Expect a drive time of about 9 hours.
Total Distance: 885 km driving distance; 720 km air distance.
The stretch through the mountains is scenic but requires careful driving.
Spring or autumn to avoid the peak summer heat and humidity.