Driving
Louisa to Knoxville
Updated: 28 May 2026
The drive from Louisa to Knoxville is approximately 300 km. You will travel south on US-23 S and then I-75 S. Expect a drive time of about 4 hours. This route takes you through the scenic mountains of Eastern Kentucky and into Tennessee. Knoxville is known for its proximity to the Great Smoky Mountains.
Total Distance: 300 km driving, 260 km air distance.
Fastest Way
Driving takes about 4 hours.
Cheapest Way
Driving is the most practical and cost-effective way to make this trip.
Compare Louisa to Knoxville Routes
Driving
Direct
Duration
4 hours
Avg Price
$45 - $65 in fuel
Operator
Personal Vehicle
Route
US-23 S to I-75 S
I-75 is a major highway and is well-maintained.
Travel Tips
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Traffic TipTraffic can be heavy near the I-75 and I-40 interchange.
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ParkingDowntown Knoxville has several parking garages.
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DiningTry the local restaurants in the Market Square area.
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WalkingThe downtown area is very walkable.
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BookingNo booking is required for this drive.
Safety Tips
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Highway SafetyStay alert on the curves of I-75.
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WeatherBe aware of potential fog in the mountains.
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Vehicle PrepCheck your tire pressure before the drive.
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EmergencyKeep a basic first aid kit in your car.
People Also Ask
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Is there a bus?Public transit options are limited; driving is recommended.
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How long is the drive?The drive takes about 4 hours.
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What is the best highway?I-75 S is the primary route.
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Are there tolls?No, this route is toll-free.
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Is Knoxville safe?Like any city, stay aware of your surroundings.
Quick Info
- From Louisa, Kentucky, United States
- To Knoxville, Tennessee, United States
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Modes
Best Time to Travel
Spring or fall for beautiful scenery.
Things to Do in Knoxville
1
Market Square
Enjoy the vibrant atmosphere of this historic square featuring shops and restaurants.
2
Sunsphere
Visit this iconic structure built for the 1982 World's Fair.
3
Great Smoky Mountains National Park
Explore the nearby national park, a world-famous destination for hiking and nature.
4
University of Tennessee
Explore the campus of this major university, a central part of the city's life.
Tags
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