The route from Louisa, Kentucky to Savannah, Georgia is approximately 600 miles. You will travel south through the mountains of West Virginia and North Carolina via I-77, then cut across South Carolina on I-26 and I-95. This drive offers a dramatic transition from the Appalachian Mountains to the Atlantic coast. Expect a drive time of about 10 hours.
Total Distance: 965 km driving distance; 780 km air distance.
The mountain passes on I-77 can be foggy; drive with caution.
Spring for the blooming azaleas or autumn for comfortable temperatures.