The trip from Madisonville to Biloxi is a drive of about 130 kilometers. You will head east on I-12 and then connect to I-10 East, taking you across the Mississippi state line. Expect a travel time of approximately 1.5 to 2 hours depending on traffic. Biloxi is famous for its casinos, beaches, and seafood.
Total Distance: 130 km driving, 110 km air distance.
I-10 can have heavy traffic near major cities; plan accordingly.
Anytime, but avoid peak rush hour traffic on I-10.