The drive from Mammoth Lakes to Las Vegas is a 500-kilometer journey that takes you south through the Eastern Sierra and then across the Nevada desert. You will follow US-395 South and then transition to US-95 South. The trip typically takes 5.5 to 6 hours. This route is a popular way to reach the entertainment capital of the world from the mountains.
Total Distance: 500 km driving distance; 400 km straight-line air distance.
Stop in Tonopah for a break.
Spring or Fall to avoid summer desert heat.