The drive from Mammoth Lakes to San Diego is a 750-kilometer journey that takes you south through the Eastern Sierra and the Mojave Desert. You will follow US-395 South and then transition to I-15 South. The trip typically takes 8 to 9 hours. This route is a popular way to reach the coast from the mountains.
Total Distance: 750 km driving distance; 650 km straight-line air distance.
Stop in Victorville for a break before the final stretch to San Diego.
Spring or Fall to avoid winter snow closures and summer desert heat.