The drive from Mt Vernon to Des Moines is approximately 650 kilometers, typically taking 6 to 7 hours. The route follows I-57 North to I-80 West, passing through the outskirts of Chicago or via the I-74 corridor depending on traffic. This is a straightforward Midwest drive through agricultural landscapes. It is a very manageable trip for a single day of driving.
Total Distance: 650 km driving, 550 km air distance.
Check traffic near the Quad Cities before departing.
Late spring or early fall for pleasant outdoor weather.