The journey from Mt Vernon to Louisville spans approximately 200 miles primarily via I-64 East. You will cross the Wabash River into Indiana before entering Kentucky. The drive typically takes 3 hours under normal traffic conditions. This route is a major corridor connecting Southern Illinois to the Ohio River Valley. Expect rolling hills and scenic farmland as you traverse the tri-state region.
Total Distance: 322 km driving distance; 290 km straight-line air distance.
Check for construction near the Sherman Minton Bridge before entering Louisville.
May through October for pleasant weather and clear road conditions.