The drive from Mt Vernon to Omaha is approximately 750 kilometers, taking about 7 to 8 hours. The most direct route involves taking I-64 West to I-70 West, then heading north through Missouri and Iowa via I-29 North. This is a straightforward drive through the heart of the Midwest, passing through St. Louis and Kansas City. It is a manageable one-day trip for most drivers.
Total Distance: 750 km driving, 650 km air distance.
Stop in Kansas City for world-famous barbecue.
Late spring or early fall for pleasant outdoor weather.