The drive from Murrells Inlet to Miami covers approximately 1000 kilometers. You will primarily use I-95 South. The journey takes about 10 hours. You will travel through the South Carolina Lowcountry, Georgia, and the entire length of Florida. This is a very long drive, so plan for multiple stops and overnight stays if necessary.
Total Distance: 1000 km driving distance; 920 km straight-line air distance.
Expect heavy traffic in South Florida.
Winter and spring offer the best weather for visiting Miami.