How long is the drive?

It takes about 6 hours and 30 minutes.

Is it a scenic drive?

It is mostly interstate driving.

Yes, some sections of Florida highways have tolls.

What is the best highway?

I-95 South to I-4 West is the primary route.

Yes, it is a very common and safe route.

Murrells Inlet

Orlando

Driving

Murrells Inlet to Orlando

Updated: 28 May 2026

The drive from Murrells Inlet to Orlando covers approximately 650 kilometers. You will primarily use I-95 South to I-4 West. The journey takes about 6 hours and 30 minutes. You will travel through the South Carolina Lowcountry, Georgia, and into Central Florida. This is a popular route for tourists, so expect heavy traffic near major cities.

Total Distance: 650 km driving distance; 580 km straight-line air distance.

Fastest Way

Driving via I-95 and I-4 is the fastest route, taking about 6.5 hours.

Cheapest Way

Driving is the most cost-effective way to reach Orlando.

Compare Murrells Inlet to Orlando Routes

Driving

Direct

Duration

6 hours 30 mins

Avg Price

$100-$130 in fuel

Operator

Personal Vehicle

Route

I-95 South to I-4 West through Jacksonville.

Expect significant traffic on I-4 near the theme parks.

Travel Tips

Traffic
Avoid I-4 during rush hour to save significant time.
Parking
Theme park parking can be expensive; consider staying on-site.
Dining
Orlando has a diverse food scene; try the restaurants in the International Drive area.
Events
Check the theme park calendars for special events and crowd levels.
Navigation
Use a GPS to monitor traffic delays on I-4.