The drive from Murrells Inlet to Wilmington is a short, 110-kilometer trip along the coast. You will primarily use US-17 North. The journey takes about 1 hour and 45 minutes. You will pass through scenic coastal towns like North Myrtle Beach and Calabash. This is a very easy and pleasant drive with minimal traffic outside of peak summer weekends.
Total Distance: 110 km driving distance; 95 km straight-line air distance.
Watch for speed limit changes in small towns along the route.
Late spring and early autumn offer the best weather for beach activities.