How long is the drive from Opelika to Des Moines?

It takes approximately 15 hours of driving time.

Are there direct flights to Des Moines?

No, you will need to connect through a hub like Chicago or Denver.

What is the best route to drive?

Taking I-65 N to I-35 N is the most direct path.

Is Des Moines safe for tourists?

Yes, it is considered a safe and friendly city.

What is the main airport in Des Moines?

Des Moines International Airport (DSM) is the primary airport.

Opelika

Des Moines

Flight Driving

Opelika to Des Moines

Updated: 28 May 2026

To travel from Opelika to Des Moines, you can drive approximately 1,600 kilometers via I-65 N and I-35 N. This road trip takes about 15 hours. Alternatively, you can fly from Atlanta to Des Moines International Airport with a connection. Flying takes about 6 hours total. This route takes you through the heart of the American agricultural belt.

Total Distance: Driving distance is 1,600 km; air distance is 1,350 km.

Fastest Way

Flight from Atlanta to Des Moines, taking about 6 hours.

Cheapest Way

Driving is the most economical option for families.

Compare Opelika to Des Moines Routes

	Flight Connecting	Driving Direct
Duration	6 hours	15 hours
Avg Price	350-700 USD	230 USD (fuel)
Operator	United Airlines	Personal Vehicle
Route	Fly from ATL to DSM.	I-65 N to I-35 N through Nashville and St. Louis.
Tip	Check for flights with short layovers in Chicago.	Plan your stops in St. Louis for a break.

Travel Tips

Driving
Be prepared for heavy traffic near St. Louis.
Navigation
Download offline maps for rural stretches of I-35.
Packing
Bring comfortable walking shoes for exploring the city.
Accommodation
Stay in the downtown area for easy access to attractions.
Local Transport
A car is recommended for visiting areas outside the city center.

Safety Tips

Fatigue
Switch drivers if possible to maintain alertness.
Weather
Check for winter storm warnings if traveling between November and March.
Emergency
Keep a charged phone and power bank at all times.
Night Driving
Be cautious of deer crossing the road in rural Iowa.