The drive from Orange Beach to Biloxi is a quick 100-kilometer trip along the Gulf Coast. You will head west on AL-182 and then merge onto I-10 West. The drive typically takes 1.5 hours. You will pass through the scenic coastal towns of Gulf Shores and Mobile before entering Mississippi. This route is popular for weekend getaways to the Biloxi casinos.
Total Distance: 100 km driving distance; 90 km straight-line air distance.
The I-10 bridge over Mobile Bay offers great views.
Spring and Fall for pleasant weather and fewer crowds.