Driving
Orangeburg to Florence
Updated: 28 May 2026
The drive from Orangeburg to Florence is a 110 km trip heading northeast. You will reach the city in about 75 minutes. This route connects the central part of the state to the Pee Dee region. The drive is mostly flat and passes through rural landscapes. It is a simple route with minimal traffic.
Total Distance: Driving distance 110 km, straight-line air distance 95 km.
Fastest Way
Driving via US-301 and I-95, taking 75 minutes.
Cheapest Way
Personal vehicle, costing approximately $15 in fuel.
Compare Orangeburg to Florence Routes
Driving
Direct
Duration
1 hour 15 mins
Avg Price
$15
Operator
Personal Vehicle
Route
US-301 North to I-95 North.
I-95 can be busy with through-traffic; stay alert.
Travel Tips
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ParkingParking is generally easy in Florence.
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DiningTry the local Southern cuisine.
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NavigationThe city is easy to navigate.
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WeatherCheck the forecast before your trip.
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Rest StopsThere are many stops along I-95.
Safety Tips
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SpeedingWatch for speed changes on I-95.
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Vehicle CheckCheck your tires before the drive.
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EmergencyKeep a first aid kit in your car.
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Distracted DrivingStay focused on the road.
People Also Ask
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How long is the drive?It takes about 75 minutes.
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Is there a train?Amtrak has a station in Florence.
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What is the best route?US-301 and I-95 are the standard routes.
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Are there tolls?No, there are no tolls on this route.
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Is it a scenic drive?It is a standard highway drive.
Quick Info
- From Orangeburg, South Carolina, United States
- To Florence, South Carolina, United States
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Modes
Best Time to Travel
Any time of year.
Things to Do in Florence
1
Florence County Museum
Learn about the history and art of the region.
2
Timrod Park
Enjoy a relaxing walk in this historic park.
3
Darlington Raceway
Visit the famous track nearby.
4
War Between the States Museum
Explore the local history museum.
Tags
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