How long is the drive?

The drive takes approximately 5 hours.

Is I-40 the best route?

Yes, I-40 is the most direct highway.

There are no tolls on this route.

Is Knoxville walkable?

The downtown area is very walkable.

Orangeburg

Knoxville

Driving

Orangeburg to Knoxville

Updated: 28 May 2026

The drive from Orangeburg to Knoxville is approximately 320 miles. You will head west on I-26 before connecting to I-40 West. This route takes you through the heart of the Appalachian mountains. Knoxville is a gateway to the Great Smoky Mountains.

Total Distance: 510 km driving distance; 450 km straight-line air distance.

Fastest Way

Driving via I-26 and I-40 is the fastest route, taking 5 hours.

Cheapest Way

Driving is the most affordable and convenient option.

Compare Orangeburg to Knoxville Routes

Driving

Direct

Duration

5 hours

Avg Price

$50-$75 in fuel

Operator

Personal Vehicle

Route

I-26 West to I-40 West.

The mountain passes on I-26 can be foggy; drive with headlights on.

Travel Tips

Mountain Driving
Be prepared for winding roads on I-26.
Dining
Knoxville has a great selection of local restaurants.
Navigation
Standard GPS works well for this route.
Parking
Downtown Knoxville has plenty of parking.
Weather
Mountain weather can change; pack layers.

Safety Tips

Highway Safety
Stay alert for heavy truck traffic on I-40.
Vehicle Check
Check your brakes before mountain driving.
Night Driving
Avoid mountain driving at night if possible.
Emergency Prep
Keep a basic emergency kit in your car.