Flight
Driving
Portsmouth to St. Louis
Updated: 28 May 2026
The journey from Portsmouth to St. Louis covers approximately 1,250 miles. Driving involves taking I-90 West to I-70 West. Flying from Boston Logan (BOS) to St. Louis Lambert International Airport (STL) is the most efficient way to travel. The route takes you through the industrial heartland and across the Mississippi River.
Total Distance: 2,010 km driving distance; 1,650 km straight-line air distance.
Fastest Way
Flying from Boston Logan (BOS) takes about 6 hours total.
Cheapest Way
Driving is the most cost-effective for groups.
Compare Portsmouth to St. Louis Routes
|
Connecting
|
Direct
|
|
|---|---|---|
| Duration | 6 hours | 20 hours |
| Avg Price | $280 - $500 | $210 - $300 in fuel |
| Operator | Southwest Airlines | Personal Vehicle |
| Route | BOS to STL via MDW or BWI | I-90 W, I-70 W |
| Tip | Southwest offers frequent connections to St. Louis. | The drive through Ohio and Indiana is straightforward but can be monotonous. |
Travel Tips
-
TransportationThe MetroLink light rail is a great way to get around the city.
-
FoodTry the famous St. Louis-style pizza and toasted ravioli.
-
WeatherBe prepared for hot, humid summers.
-
ParkingUse parking garages in the downtown area.
-
NavigationI-70 can be busy; use traffic apps.
Safety Tips
-
Urban SafetyStay in well-lit, populated areas at night.
-
Vehicle SecurityDo not leave valuables in your car.
-
Road SafetyBe cautious of heavy traffic on I-70.
-
EmergencyKeep a list of local emergency contacts.
People Also Ask
-
Is there a train to St. Louis?Yes, Amtrak's Lincoln Service and Texas Eagle serve St. Louis.
-
How long is the drive?Approximately 20 hours of driving time.
-
Are there tolls?Yes, expect tolls on the East Coast and Midwest turnpikes.
-
Is St. Louis safe?Exercise standard city safety precautions.
-
What is the best way to get around?A rental car is recommended.
Quick Info
- From Portsmouth, New Hampshire, United States
- To St. Louis, Missouri, United States
-
Modes
Best Time to Travel
May and October for mild weather and outdoor activities.
Things to Do in St. Louis
1
Gateway Arch
Visit the iconic monument. Take the tram to the top for incredible views of the city and river.
2
Forest Park
Explore one of the largest urban parks in the US. It houses the zoo, art museum, and science center.
3
City Museum
Experience a unique playground made of recycled materials. It is fun for all ages.
4
Anheuser-Busch Brewery
Take a tour of the historic brewery and see the famous Clydesdale horses.
Tags
Portsmouth to St. Louis travel
driving NH to Missouri
flights from PSM to STL
best route Portsmouth to St. Louis
traveling across US
NH to MO road trip
St. Louis travel guide
Portsmouth transport options
