The drive from Reno to Sioux Falls is approximately 2,200 kilometers. The route takes you east through Nevada, Utah, Wyoming, Nebraska, and into South Dakota via I-80 and I-29. This journey takes about 22 to 24 hours. Sioux Falls is the largest city in South Dakota, known for its namesake waterfalls.
Total Distance: 2,200 km driving distance; 1,700 km straight-line air distance.
This is a very long drive; plan for multiple overnight stops.
Spring or Fall for mild weather.