The drive from Shepherdsville to Washington, D.C. is approximately 600 miles, primarily using I-64 East and I-81 North. You will travel through the Appalachian Mountains and the Shenandoah Valley before reaching the nation's capital. The drive typically takes 9 hours. This is a scenic but long interstate route.
Total Distance: 960 km driving distance; 750 km straight-line air distance.
The mountain passes on I-64 and I-81 can be challenging in bad weather.
Spring or Autumn for the best weather in Washington, D.C.