The most practical way to travel from Sioux Falls to San Francisco is by air. You will fly from Sioux Falls Regional Airport (FSD) to San Francisco International Airport (SFO), typically with one connection. The total travel time is around 6-7 hours. Driving is not recommended due to the 1,700-mile distance.
Total Distance: 2,750 km driving, 2,300 km air distance.
SFO is well-connected to the city via the BART train.
Spring or autumn for the best weather.