Yes, but it is a 10-hour drive.

What is the best airport?

St. Louis Lambert International (STL).

St. Louis is a mid-cost city; budget accordingly.

St. Cloud

St. Louis

Flight Driving

St. Cloud to St. Louis

Updated: 29 May 2026

The most practical way to reach St. Louis from St. Cloud is to drive to Minneapolis-St. Paul International Airport (MSP) and take a direct flight to St. Louis Lambert International Airport (STL). The flight takes approximately 1.5 hours. Driving is a long journey of over 600 miles, taking at least 10 hours of driving time. St. Louis is a major city, and renting a car is recommended for exploring the area.

Total Distance: 1,000 km driving distance; 800 km straight-line air distance.

Fastest Way

Flying from MSP is the fastest method, saving over 8 hours of travel time.

Cheapest Way

Flying is significantly cheaper and faster than the fuel and hotel costs of a long drive.

Compare St. Cloud to St. Louis Routes

	Flight Direct	Driving Direct
Duration	1.5 hours	10 hours
Avg Price	$150-$300 round trip	$150-$250 in fuel
Operator	Southwest Airlines	Personal Vehicle
Route	MSP to STL.	I-94 E to I-35 S to I-70 E.
Tip	Southwest and other carriers offer frequent direct flights from MSP.	This is a long day of driving; plan for frequent breaks.

Travel Tips

Traffic
St. Louis traffic is heavy; avoid driving during rush hours.
Transit
Use the MetroLink light rail system to navigate the city.
Airport
STL is very busy; allow extra time for security and terminal transfers.
Booking
Book hotels in the downtown or Central West End areas for easy access to attractions.
Dining
Explore the diverse food scene in neighborhoods like the Hill and Soulard.

Safety Tips

Awareness
Stay alert in crowded tourist areas and on public transit.
Driving
Be prepared for heavy traffic and aggressive driving on St. Louis freeways.
Emergency
Keep your hotel address and emergency contacts handy.
Sun Safety
The Missouri sun is strong; wear sunglasses and sunscreen.