The drive from Tyler to Memphis is a straightforward 650 km journey. You will head north on US-259 and US-59, then merge onto I-30 East toward Little Rock, and finally take I-40 East into Memphis. This route takes you through the piney woods of East Texas and the flatlands of the Mississippi Delta. It is a manageable one-day drive.
Total Distance: 650 km driving distance; 580 km air distance.
Stop in Little Rock for a quick lunch break.
Spring or Fall to enjoy the outdoor festivals and comfortable temperatures.