The journey from Winston-Salem to Columbus covers approximately 650 kilometers. The most efficient route involves taking I-77 North through the Appalachian Mountains. You will cross into West Virginia before entering Ohio. This drive typically takes 7 hours depending on traffic near Charlotte or Charleston. The route offers scenic views of the Blue Ridge Mountains.
Total Distance: 650 km driving, 520 km air distance.
Check for construction delays near the West Virginia border.
September to October for mild weather and fall foliage.