Winston-Salem
Winston-Salem
St. Louis
St. Louis
Driving

Winston-Salem to St. Louis

Updated: 28 May 2026

The drive from Winston-Salem to St. Louis covers approximately 1,050 kilometers. You will head west through Tennessee and Kentucky before entering Missouri. The primary highways are I-40 and I-64. Expect a travel time of about 11 hours. This route crosses the Mississippi River as you arrive.

Total Distance: 1,050 km driving, 900 km air distance.
Fastest Way
Driving is the fastest practical way to reach St. Louis.
Cheapest Way
Driving is the most cost-effective option.
Compare Winston-Salem to St. Louis Routes
Driving
Direct
Duration
11 hours
Avg Price
$130-$190 in fuel
Operator
Personal Vehicle
Route
I-40 W to I-64 W

Louisville is a great place to stop for lunch.

Travel Tips
  • Traffic
    Expect congestion near Louisville and St. Louis.
  • Rest Stops
    Use the rest areas in Kentucky for breaks.
  • Navigation
    Use GPS to find the best route through Nashville if needed.
  • Hydration
    Keep plenty of water for the long drive.
  • Snacks
    Pack a cooler with food to save money.
Safety Tips
  • Fatigue
    Switch drivers if possible to stay alert.
  • Speed Limits
    Watch for speed traps in rural Tennessee.
  • Weather
    Check for storms in the Midwest plains.
  • Vehicle Check
    Check tire pressure before leaving.
People Also Ask
  • Is St. Louis safe?
    Stick to tourist areas and be aware of your surroundings.
  • How long is the drive?
    It takes about 11 hours.
  • Are there flights?
    Flights are available but require connections.
  • What is the best route?
    I-40 W to I-64 W is the standard path.
  • Is it a scenic route?
    The drive through Kentucky is quite beautiful.
Quick Info
  • From Winston-Salem, North Carolina, United States
  • To St. Louis, Missouri, United States
  • Modes
Best Time to Travel

Spring or Fall for comfortable temperatures.

Things to Do in St. Louis
1
Gateway Arch
The iconic monument of St. Louis. You can take a tram to the top.
2
Forest Park
A massive urban park home to the zoo and art museum. It is free to enter.
3
City Museum
An incredible playground for all ages made of recycled materials. It is a unique experience.
4
Anheuser-Busch Brewery
Take a tour of the historic brewery. It is a staple of St. Louis culture.
Tags
Winston-Salem to St. Louis driving to Missouri I-40 to I-64 St. Louis travel guide NC to MO road trip long distance driving best route to St. Louis traveling west
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