Flight
Driving
Ankeny to Louisville
Updated: 28 May 2026
The journey from Ankeny to Louisville covers approximately 600 miles. The most direct driving route is via I-80 East to I-65 South, passing through Illinois and Indiana. This is a straightforward drive through the heart of the Midwest. Alternatively, you can fly from Des Moines International Airport to Louisville Muhammad Ali International Airport. Flying is the most efficient option.
Total Distance: 965 km driving, 850 km air distance.
Fastest Way
Flying is the fastest, taking about 4 hours total.
Cheapest Way
Driving is the most cost-effective for groups.
Compare Ankeny to Louisville Routes
|
Connecting
|
Direct
|
|
|---|---|---|
| Duration | 4 hours | 9 hours |
| Avg Price | $300-$500 | $110-$160 in fuel |
| Operator | American Airlines | Personal Vehicle |
| Route | DSM to SDF via Chicago or Charlotte. | I-80 E, I-65 S. |
| Tip | Book early to secure better flight connections. | Indianapolis is a great halfway point for a lunch break. |
Travel Tips
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Airport TransitSDF is about 15 minutes from downtown; use ride-shares for easy access.
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WalkingDowntown Louisville is very walkable.
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EventsCheck for Derby-related events before booking your trip.
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SafetyStay in well-traveled areas and avoid walking alone late at night.
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FoodTry the famous Hot Brown sandwich while in the city.
Safety Tips
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Urban SafetyKeep your belongings secure in crowded tourist areas.
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DrivingBe cautious of heavy traffic on I-65 near Louisville.
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Emergency KitKeep a first-aid kit and water in your car for the long drive.
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NavigationUse GPS to avoid getting lost in the city's complex street layout.
People Also Ask
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Is there a train?No direct train service exists between Ankeny and Louisville.
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How long is the drive?Approximately 9 to 10 hours of driving time.
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Are there tolls?Some parts of the route may have tolls.
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Is it better to fly?Yes, flying is much faster for this distance.
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What is the best route?I-80 to I-65 is the most common path.
Quick Info
- From Ankeny, Iowa, United States
- To Louisville, Kentucky, United States
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Modes
Best Time to Travel
May for the Kentucky Derby or Fall for pleasant weather.
Things to Do in Louisville
1
Churchill Downs
Visit the home of the Kentucky Derby and tour the museum.
2
Louisville Slugger Museum
See how the famous baseball bats are made and tour the factory.
3
Muhammad Ali Center
Explore the life and legacy of the legendary boxer in this interactive museum.
4
Big Four Bridge
Walk or bike across this historic bridge connecting Louisville to Jeffersonville, Indiana.
Tags
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