The drive from Bishop to Palmdale is approximately 340 kilometers. You will head south on US-395 before turning onto CA-14 through the Mojave Desert. The journey typically takes 3.5 to 4 hours. Be prepared for desert heat and potential high winds in the Antelope Valley.
Total Distance: 340 km driving distance; 290 km straight-line air distance.
Stop in Mojave for a quick break.
Spring or Fall for the most comfortable temperatures.