Is there a train to Birmingham?

Amtrak's Crescent line stops in Birmingham, but there is no rail service from Cape Girardeau.

How long is the drive?

The drive takes about 6 hours and 30 minutes.

What is the best route?

I-55 to I-22 is the standard and most efficient route.

There are no direct commercial flights between these two cities.

Cape Girardeau

Birmingham

Driving

Cape Girardeau to Birmingham

Updated: 28 May 2026

The journey from Cape Girardeau to Birmingham covers approximately 400 miles. You will head south on I-55 to Memphis, then take I-22 East to reach Birmingham. This route takes you through the heart of the South. The total driving time is approximately 6.5 to 7 hours. It is a direct and efficient route that connects the Midwest to the Southeast.

Total Distance: 645 km driving distance, 520 km straight-line air distance.

Fastest Way

Driving via I-55 and I-22 is the fastest and most direct route.

Cheapest Way

Driving your own vehicle is the most cost-effective way to make this trip.

Compare Cape Girardeau to Birmingham Routes

Driving

Direct

Duration

6 hours 30 mins

Avg Price

$70-$90 in fuel

Operator

Personal Vehicle

Route

I-55 South to Memphis, I-22 East to Birmingham.

Be prepared for heavy traffic in Birmingham.

Travel Tips

Birmingham Traffic
Avoid driving in Birmingham during morning and evening rush hours.
Rest Stops
There are many service plazas along the interstate route.
Dining
Try authentic Southern barbecue at a local restaurant in Birmingham.
Navigation
Use a GPS to navigate the city streets of Birmingham.
Fuel
Gas prices are often lower in rural areas than in the city.