Is there a train to Cincinnati?

Amtrak's Cardinal line stops in Cincinnati, but there is no rail service from Cape Girardeau.

Some bridges in the Cincinnati area may have tolls.

What is the best route?

I-64 to I-71 is the standard and most efficient route.

There are no direct commercial flights between these two cities.

Cape Girardeau

Cincinnati

Driving

Cape Girardeau to Cincinnati

Updated: 28 May 2026

The journey from Cape Girardeau to Cincinnati covers approximately 380 miles. You will head east on IL-146 and I-64 through southern Illinois and Indiana, then take I-71 North to reach Cincinnati. This route takes you through the scenic landscape of the Ohio River valley. The total driving time is approximately 6 hours. It is a direct and efficient route connecting the two states.

Total Distance: 610 km driving distance, 500 km straight-line air distance.

Fastest Way

Driving via I-64 and I-71 is the fastest and most direct route.

Cheapest Way

Driving your own vehicle is the most cost-effective way to make this trip.

Compare Cape Girardeau to Cincinnati Routes

Driving

Direct

Duration

6 hours

Avg Price

$70-$90 in fuel

Operator

Personal Vehicle

Route

IL-146 East to I-64 East to I-71 North to Cincinnati.

Be prepared for heavy traffic in Cincinnati.

Travel Tips

Cincinnati Traffic
Avoid driving in Cincinnati during morning and evening rush hours.
Rest Stops
There are many service plazas along the interstate route.
Dining
Try authentic Cincinnati-style chili at a local restaurant.
Navigation
Use a GPS to navigate the city streets of Cincinnati.
Fuel
Gas prices are often lower in rural areas than in the city.