Is there a train to Columbus?

There is no direct passenger rail service to Columbus from Cape Girardeau.

How long is the drive?

The drive takes about 7 hours and 30 minutes.

Some sections of the Ohio road network may have tolls.

What is the best route?

I-64 to I-70 is the standard and most efficient route.

There are no direct commercial flights between these two cities.

Cape Girardeau

Columbus

Driving

Cape Girardeau to Columbus

Updated: 28 May 2026

The journey from Cape Girardeau to Columbus covers approximately 480 miles. You will head east on IL-146 and I-64 through southern Illinois and Indiana, then take I-70 East to reach Columbus. This route takes you through the heart of the Midwest. The total driving time is approximately 7.5 to 8 hours. It is a direct and efficient route connecting the two states.

Total Distance: 770 km driving distance, 620 km straight-line air distance.

Fastest Way

Driving via I-64 and I-70 is the fastest and most direct route.

Cheapest Way

Driving your own vehicle is the most cost-effective way to make this trip.

Compare Cape Girardeau to Columbus Routes

Driving

Direct

Duration

7 hours 30 mins

Avg Price

$90-$120 in fuel

Operator

Personal Vehicle

Route

IL-146 East to I-64 East to I-70 East to Columbus.

Be prepared for heavy traffic in Columbus.

Travel Tips

Columbus Traffic
Avoid driving in Columbus during morning and evening rush hours.
Rest Stops
There are many service plazas along the interstate route.
Dining
Try authentic Midwestern cuisine at a local restaurant in Columbus.
Navigation
Use a GPS to navigate the city streets of Columbus.
Fuel
Gas prices are often lower in rural areas than in the city.