Is there a train to Minneapolis?

Amtrak's Empire Builder line stops in Minneapolis, but there is no rail service from Cape Girardeau.

How long is the drive?

The drive takes about 10 hours.

Some sections of the Minnesota road network may have tolls.

What is the best route?

I-55 to I-70 to I-35 is the standard and most efficient route.

There are no direct commercial flights between these two cities.

Cape Girardeau

Minneapolis

Driving

Cape Girardeau to Minneapolis

Updated: 28 May 2026

The journey from Cape Girardeau to Minneapolis covers approximately 650 miles. You will head north on I-55 to St. Louis, then take I-70 and I-35 to reach Minneapolis. This route takes you through the heart of the Midwest. The total driving time is approximately 10 to 11 hours. It is a direct and efficient route connecting the two states.

Total Distance: 1050 km driving distance, 850 km straight-line air distance.

Fastest Way

Driving via I-55, I-70, and I-35 is the fastest and most direct route.

Cheapest Way

Driving your own vehicle is the most cost-effective way to make this trip.

Compare Cape Girardeau to Minneapolis Routes

Driving

Direct

Duration

10 hours

Avg Price

$120-$150 in fuel

Operator

Personal Vehicle

Route

I-55 North to St. Louis, I-70 West to I-35 North to Minneapolis.

Be prepared for heavy traffic in Minneapolis.

Travel Tips

Minneapolis Traffic
Avoid driving in Minneapolis during morning and evening rush hours.
Rest Stops
There are many service plazas along the interstate route.
Dining
Try authentic Midwestern cuisine at a local restaurant in Minneapolis.
Navigation
Use a GPS to navigate the city streets of Minneapolis.
Fuel
Gas prices are often lower in rural areas than in the city.