Is there a train to New Orleans?

Amtrak's City of New Orleans line stops in New Orleans, but there is no rail service from Cape Girardeau.

Some bridges in the New Orleans area may have tolls.

What is the best route?

I-55 South is the standard and most efficient route.

There are no direct commercial flights between these two cities.

Cape Girardeau

New Orleans

Driving

Cape Girardeau to New Orleans

Updated: 28 May 2026

The journey from Cape Girardeau to New Orleans covers approximately 600 miles. You will head south on I-55 all the way to New Orleans. This route takes you through the heart of the Mississippi River valley. The total driving time is approximately 9 to 10 hours. It is a direct and efficient route that connects the Midwest to the Gulf Coast.

Total Distance: 965 km driving distance, 800 km straight-line air distance.

Fastest Way

Driving via I-55 is the fastest and most direct route.

Cheapest Way

Driving your own vehicle is the most cost-effective way to make this trip.

Compare Cape Girardeau to New Orleans Routes

Driving

Direct

Duration

9 hours

Avg Price

$110-$140 in fuel

Operator

Personal Vehicle

Route

I-55 South all the way to New Orleans.

Be prepared for heavy traffic in New Orleans.

Travel Tips

New Orleans Traffic
Avoid driving in New Orleans during morning and evening rush hours.
Rest Stops
There are many service plazas along the interstate route.
Dining
Try authentic Cajun or Creole cuisine at a local restaurant in New Orleans.
Navigation
Use a GPS to navigate the city streets of New Orleans.
Fuel
Gas prices are often lower in rural areas than in the city.