What is the best airport?

Tampa International Airport (TPA) is highly rated for convenience.

Yes, some expressways in the Tampa area are toll-based.

Tampa is moderately priced compared to other Florida tourist hubs.

Cape Girardeau

Tampa

Flight Driving

Cape Girardeau to Tampa

Updated: 28 May 2026

The trip from Cape Girardeau to Tampa spans approximately 1,700 kilometers. Flying from St. Louis to Tampa International Airport (TPA) is the most efficient method. Driving takes about 17 hours via I-55, I-24, and I-75. Tampa is known for its beautiful Gulf Coast beaches and the historic Ybor City district. Plan your travel to avoid the peak summer heat and hurricane season.

Total Distance: 1,750 km driving distance; 1,450 km straight-line air distance.

Fastest Way

Flight from St. Louis Lambert International Airport is the fastest, taking roughly 5 hours.

Cheapest Way

Driving is the most cost-effective for groups.

Compare Cape Girardeau to Tampa Routes

	Flight Connecting	Driving Direct
Duration	5 hours	17 hours
Avg Price	$180 - $400	$280 - $450 in fuel
Operator	Delta Air Lines	Personal Vehicle
Route	STL to TPA via Atlanta.	I-55 S to I-24 E to I-75 S.
Tip	Atlanta is a major hub for flights to Tampa.	The drive through Georgia and Florida is mostly flat and straightforward.

Travel Tips

Sun Protection
The Florida sun is intense; wear high-SPF sunscreen daily.
Transportation
Use the TECO Line Streetcar to travel between Ybor City and downtown.
Beach Access
Drive to nearby Clearwater or St. Pete Beach for the best Gulf Coast sand.
Dining
Try a Cuban sandwich in Ybor City; it is a local specialty.
Weather
Check for afternoon rain showers during the summer months.

Safety Tips

Water Safety
Always swim near lifeguard towers and check for rip current warnings.
Hurricane Awareness
Monitor weather reports if traveling during the hurricane season.
Urban Safety
Stay in well-lit, populated areas when visiting Ybor City at night.
Emergency
Dial 911 for any emergency assistance.