Bus
Driving
Des Moines to Chicago
Updated: 28 May 2026
The journey from Des Moines to Chicago is a 500-kilometer trip across the Midwest. Driving via I-80 East is the most common method, taking about five hours. Alternatively, you can take a bus or drive to a nearby Amtrak station for a train connection. Chicago offers world-class museums, architecture, and dining, making it a popular destination from Iowa.
Total Distance: 500 km driving distance; 480 km straight-line air distance.
Fastest Way
Driving your own vehicle is the fastest way, taking about 5 hours.
Cheapest Way
Bus travel is the most economical option for solo travelers.
Compare Des Moines to Chicago Routes
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Direct
|
Direct
|
|
|---|---|---|
| Duration | 6 hours 30 mins | 5 hours |
| Avg Price | $40 - $80 | $60 - $100 in fuel |
| Operator | Jefferson Lines | Personal Vehicle |
| Route | Des Moines to Chicago Union Station. | I-80 E to I-88 E. |
| Tip | Book tickets in advance for the best prices. | Expect tolls on I-88 as you approach the Chicago area. |
Travel Tips
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TrafficAvoid driving into Chicago during morning and evening rush hours.
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Public TransitThe 'L' train system is the best way to get around the city.
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WeatherWinters are very cold and windy; pack heavy layers.
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DiningTry a deep-dish pizza; it is a Chicago staple.
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ParkingParking in downtown Chicago is expensive; use public transit or parking apps.
Safety Tips
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GeneralChicago is generally safe, but stay aware of your surroundings in downtown at night.
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Pedestrian SafetyBe cautious when crossing busy streets.
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EmergencyKeep a winter emergency kit in your car if traveling in winter.
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Public TransitStay alert on public transit, especially late at night.
People Also Ask
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Is Chicago safe?Yes, most tourist areas are safe, but stay aware of your surroundings.
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What is the best way to get around?The 'L' train and bus system are excellent.
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Is deep-dish pizza good?It is a unique and filling experience that every visitor should try.
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Are there many museums?Yes, Chicago has some of the best museums in the country.
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Is it expensive?It is moderately priced compared to major coastal cities.
Quick Info
- From Des Moines, Iowa, United States
- To Chicago, Illinois, United States
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Modes
Best Time to Travel
May to September for pleasant weather and outdoor festivals.
Things to Do in Chicago
1
Millennium Park
Home to the famous 'Bean' sculpture. It is a must-visit for any Chicago trip.
2
Art Institute of Chicago
One of the oldest and largest art museums in the US. It features iconic works like American Gothic.
3
Navy Pier
A popular destination with rides, restaurants, and boat tours. It offers great views of the lake.
4
Willis Tower Skydeck
Experience the glass floor balconies for a view from over 1,300 feet up. It is a thrilling experience.
Tags
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