Yes, most tourist areas are safe, but stay aware of your surroundings.

What is the best way to get around?

A car is essential for exploring the area effectively.

Is the Gateway Arch worth it?

Yes, it is a unique and iconic experience.

Are there many museums?

Yes, St. Louis has some great museums and cultural sites.

It is generally more affordable than major coastal cities.

Des Moines

St. Louis

Bus Driving

Des Moines to St. Louis

Updated: 28 May 2026

The journey from Des Moines to St. Louis is a 600-kilometer trip southeast. Driving is the most convenient method, taking approximately six hours. The route passes through the heart of the Midwest. St. Louis is known for the Gateway Arch, its rich history, and vibrant culture.

Total Distance: 600 km driving distance; 550 km straight-line air distance.

Fastest Way

Driving your own vehicle is the fastest way, taking about 6 hours.

Cheapest Way

Bus travel is the most economical option for solo travelers.

Compare Des Moines to St. Louis Routes

	Bus Direct	Driving Direct
Duration	7 hours	6 hours
Avg Price	$50 - $90	$70 - $110 in fuel
Operator	Jefferson Lines	Personal Vehicle
Route	Des Moines to St. Louis.	US-65 S to I-70 E.
Tip	Book tickets in advance for the best prices.	The drive is straightforward and mostly flat.

Travel Tips

Dining
Try toasted ravioli; it is a local specialty.
Transport
A car is recommended for exploring the city effectively.
Culture
Explore the historic Soulard district.
Weather
Summers are hot and humid; pack light clothing.
Events
Check the calendar for local festivals and events.

Safety Tips

General
St. Louis is generally safe, but stay aware of your surroundings in downtown at night.
Pedestrian Safety
Be cautious when crossing busy streets.
Emergency
Keep a water bottle with you at all times.
Public Transit
Stay alert on public transit, especially late at night.