Flight
Driving
Des Peres to Columbus
Updated: 31 May 2026
The journey from Des Peres to Columbus spans approximately 650 kilometers primarily via Interstate 70 East. Driving takes roughly six hours depending on traffic through Indianapolis. Alternatively, you can fly from St. Louis Lambert International Airport to John Glenn Columbus International Airport. This route traverses the heart of the Midwest, passing through Illinois and Indiana. Expect varied terrain ranging from flat plains to rolling hills as you approach central Ohio.
Total Distance: 650 km driving, 580 km air distance.
Fastest Way
Driving is generally faster than flying due to layovers and airport security.
Cheapest Way
Driving is the most cost-effective method for groups or solo travelers.
Compare Des Peres to Columbus Routes
|
Connecting
|
Direct
|
|
|---|---|---|
| Duration | 3 hours 30 mins | 6 hours 15 mins |
| Avg Price | $250-$400 | $70-$100 in fuel |
| Operator | Southwest Airlines | Personal Vehicle |
| Route | STL to CMH via Chicago or Baltimore. | I-70 East through Indianapolis and Dayton. |
| Tip | Book at least three weeks in advance for lower fares. | Avoid rush hour traffic in downtown Indianapolis to save 30 minutes. |
Travel Tips
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Toll RoadsBe prepared for potential tolls on specific bypasses in Indiana.
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Rest StopsUse the rest areas along I-70 in Illinois for clean facilities.
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ParkingDowntown Columbus parking garages offer daily rates around $20.
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TrafficCheck local news for construction updates near the I-70/I-270 interchange.
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NavigationDownload offline maps as cellular service can be spotty in rural Indiana.
Safety Tips
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WeatherWinter storms can make I-70 hazardous; check road conditions before departing.
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FatigueTake a break every two hours to prevent driver fatigue.
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Emergency KitKeep a basic emergency kit with water and blankets in your trunk.
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Speed LimitsStrictly observe speed limits in small towns along the route.
People Also Ask
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Is there a direct train?No, there is no direct passenger rail service between these cities.
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How long is the drive?The drive typically takes between 6 and 7 hours.
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Are there tolls?Some routes through Indiana may involve toll roads.
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What is the best airport?John Glenn Columbus International Airport is the primary hub.
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Is it safe to drive at night?Yes, but be cautious of deer crossing in rural areas.
Quick Info
- From Des Peres, Missouri, United States
- To Columbus, Ohio, United States
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Modes
Best Time to Travel
May through September for clear highway conditions and mild weather.
Things to Do in Columbus
1
COSI Columbus
The Center of Science and Industry offers interactive exhibits for all ages. It is located along the Scioto River.
2
German Village
Explore this historic neighborhood known for its brick houses and cobblestone streets. Visit the Book Loft for a unique shopping experience.
3
Franklin Park Conservatory
Enjoy botanical gardens and glass art displays. It features a stunning Victorian-style glasshouse.
4
Short North Arts District
Browse local galleries and boutiques. This area is famous for its vibrant murals and nightlife.
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