Driving
Des Peres to Nashville
Updated: 31 May 2026
The drive from Des Peres to Nashville is approximately 500 km. You will take I-64 E to I-57 S, then I-24 E. The journey takes about 5 hours and 30 minutes. This route takes you through the scenic landscapes of Southern Illinois and Kentucky before arriving in Tennessee.
Total Distance: 500 km driving distance; 450 km straight-line air distance.
Fastest Way
Driving via I-24 E takes 5.5 hours.
Cheapest Way
Driving is the most economical option.
Compare Des Peres to Nashville Routes
Driving
Direct
Duration
5 hours 30 mins
Avg Price
$60 - $100
Operator
Personal Vehicle
Route
I-64 E to I-57 S to I-24 E.
Traffic in Nashville can be heavy.
Travel Tips
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TrafficAvoid Nashville rush hour traffic.
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ParkingUse parking apps to find spots downtown.
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MusicCheck the schedule for live music events.
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DiningTry Nashville hot chicken.
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NavigationUse GPS for navigating the city.
Safety Tips
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DrivingStay alert on the highway.
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WeatherCheck for weather alerts.
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VehicleCheck your car before the trip.
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EmergencyKeep a roadside kit.
People Also Ask
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How long is the drive?It takes about 5.5 hours.
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Is there a train?No, there is no direct rail service.
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Are there tolls?No, this route is toll-free.
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What is the best way?Driving is the most convenient.
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Is it safe?Yes, it is a standard drive.
Quick Info
- From Des Peres, Missouri, United States
- To Nashville, Tennessee, United States
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Modes
Best Time to Travel
Spring and Fall for mild weather.
Things to Do in Nashville
1
Grand Ole Opry
Experience the home of country music.
2
Country Music Hall of Fame
Learn about the history of country music.
3
Ryman Auditorium
Visit the historic venue known as the Mother Church of Country Music.
4
Broadway
Enjoy live music at the many honky-tonks.
Tags
Des Peres to Nashville
driving to Nashville
I-64 to I-24
Missouri to Tennessee
Nashville travel guide
road trip to Nashville
St Louis to Nashville
best way to Nashville
