Driving
Des Peres to Memphis
Updated: 31 May 2026
The drive from Des Peres to Memphis is a 450 km journey heading south. You will follow I-55 S for the entire trip, which takes about 4 hours and 30 minutes. This route is a direct path through the Mississippi River valley.
Total Distance: 450 km driving distance; 400 km straight-line air distance.
Fastest Way
Driving via I-55 S takes 4.5 hours.
Cheapest Way
Driving is the most economical option.
Compare Des Peres to Memphis Routes
Driving
Direct
Duration
4 hours 30 mins
Avg Price
$50 - $90
Operator
Personal Vehicle
Route
I-55 S.
Watch for speed traps in small towns.
Travel Tips
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TrafficAvoid Memphis rush hour.
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ParkingUse secure parking garages.
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MusicCheck for live music events.
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DiningTry Memphis-style BBQ.
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NavigationUse GPS for city navigation.
Safety Tips
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DrivingStay alert on the highway.
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WeatherCheck for weather alerts.
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VehicleCheck your car before the trip.
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EmergencyKeep a roadside kit.
People Also Ask
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How long is the drive?It takes about 4.5 hours.
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Is there a train?No, there is no direct rail service.
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Are there tolls?No, this route is toll-free.
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What is the best way?Driving is the most convenient.
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Is it safe?Yes, it is a standard drive.
Quick Info
- From Des Peres, Missouri, United States
- To Memphis, Tennessee, United States
-
Modes
Best Time to Travel
Spring and Fall for comfortable weather.
Things to Do in Memphis
1
Graceland
Visit the home of Elvis Presley.
2
Beale Street
Enjoy live blues music and nightlife.
3
National Civil Rights Museum
Learn about the history of the civil rights movement.
4
Sun Studio
Tour the historic recording studio.
Tags
Des Peres to Memphis
driving to Memphis
I-55 S route
Missouri to Tennessee
Memphis travel guide
road trip to Memphis
St Louis to Memphis
best way to Memphis
