Is there a bus to Knoxville?

No, there is no direct bus service from Highlands to Knoxville.

How long is the drive?

The drive takes about 2 hours and 30 minutes.

No, there is no passenger rail service on this route.

Yes, it is a well-traveled and safe mountain route.

What is the best time to leave?

Early morning to avoid traffic in the national park.

Highlands

Knoxville

Driving

Highlands to Knoxville

Updated: 28 May 2026

The journey from Highlands to Knoxville covers 190 kilometers, passing through the Great Smoky Mountains National Park. You will take US-64 W to US-441 N. The drive typically takes 2 hours and 30 minutes. This route is incredibly scenic, especially as you cross the mountains. It is a popular path for those traveling between the two regions.

Total Distance: 190 km driving distance; 140 km straight-line air distance.

Fastest Way

Driving via US-441 N is the fastest route, taking 2 hours and 30 minutes.

Cheapest Way

Driving your own vehicle is the most cost-effective method at 25 dollars in fuel.

Compare Highlands to Knoxville Routes

Driving

Direct

Duration

2 hours 30 mins

Avg Price

20-30 dollars

Operator

Personal Vehicle

Route

US-64 W to US-441 N.

Stop at the overlooks in the national park.

Travel Tips

Traffic
Traffic can be heavy in the national park during peak tourist season.
Parking
Use the public parking garages in downtown Knoxville.
Dining
Knoxville has a great food scene; try the local Southern cuisine.
Navigation
Use a GPS to navigate the city's streets.
Fuel
Gas prices are generally lower in Tennessee than in North Carolina.

Safety Tips

Mountain Driving
Stay alert for winding roads and steep grades in the national park.
Wildlife
Watch for bears and deer crossing the road in the national park.
Fatigue
Take a break every 2 hours to stay alert on the drive.
Emergency
Keep your phone charged and have a roadside assistance number saved.