Greyhound provides service, but it often requires transfers.

What is the best time to visit?

Spring and fall offer the most comfortable temperatures.

Is it a scenic route?

Yes, the drive through the Ozarks is quite beautiful.

Jefferson City

Memphis

Driving

Jefferson City to Memphis

Updated: 28 May 2026

The journey from Jefferson City to Memphis is a 400-kilometer drive heading southeast. You will primarily use US-63 and US-67 to reach the Mississippi River. The drive takes about 4.5 hours, crossing through the scenic Ozark foothills. This route is popular for those traveling to experience the blues music and barbecue culture of Memphis. Ensure your vehicle is prepared for winding roads in the Missouri bootheel region.

Total Distance: 400 km driving distance, 370 km air distance.

Fastest Way

Driving is the fastest, taking 4.5 hours.

Cheapest Way

Driving is the most affordable way to reach Memphis.

Compare Jefferson City to Memphis Routes

Driving

Direct

Duration

4 hours 30 mins

Avg Price

$50-$65 in fuel

Operator

Personal Vehicle

Route

US-63 S to US-67 S.

Watch for speed traps in small towns along the route.

Travel Tips

Music Scene
Check local listings for live music performances on Beale Street.
Barbecue
Try the famous dry-rub ribs at local Memphis smokehouses.
Parking
Use secure parking garages when visiting downtown Memphis.
Route Planning
Avoid taking backroads at night due to limited lighting.
Hydration
Keep water in the car, as summers in Memphis are very humid.

Safety Tips

Urban Safety
Stay in well-lit, populated areas when exploring downtown at night.
Road Hazards
Be alert for heavy truck traffic on highways near Memphis.
Weather
Be prepared for sudden thunderstorms in the afternoon.
Vehicle Security
Do not leave valuables visible in your parked car.