The drive from La Crosse to St. Louis is approximately 450 miles, primarily via I-90 and I-55 South. This route takes you across the state line into Illinois and then into Missouri. Expect a travel time of about 7 hours. Driving is the most practical and common mode of transport for this route.
Total Distance: 724 km driving, 600 km air distance.
The drive is very direct; watch for speed traps in small towns.
Summer for outdoor activities or autumn for the beautiful fall colors.