How long is the drive?

It takes about 4 hours of driving time.

There is no direct passenger train service from Lexington to Knoxville.

What is the best route?

I-26 West to I-40 West is the most direct route.

There are no major tolls on this route.

Knoxville is safe in tourist areas, but use common sense at night.

Lexington

Knoxville

Driving

Lexington to Knoxville

Updated: 31 May 2026

The drive from Lexington to Knoxville is approximately 250 miles and takes about 4 hours. You will take I-26 West to I-40 West, passing through the mountains of North Carolina and into Tennessee. This route is a popular corridor for those traveling between the two states. Expect a smooth drive with plenty of service stops along the way.

Total Distance: 400 km driving distance; 350 km straight-line air distance.

Fastest Way

Driving is the most practical method as there are no direct flights from Columbia to Knoxville.

Cheapest Way

Driving is the most affordable way to reach Knoxville from Lexington.

Compare Lexington to Knoxville Routes

Driving

Direct

Duration

4 hours

Avg Price

$40-$60 in fuel

Operator

Personal Vehicle

Route

I-26 W to I-40 W

Stop in Asheville for a quick break.

Travel Tips

Traffic
Knoxville traffic is manageable, but avoid rush hour in the city center.
Dining
Knoxville has a great food scene; try the local restaurants in the downtown area.
Navigation
I-40 is well-marked, but stay alert for lane changes.
Rest Stops
There are plenty of service stations along I-40 in Tennessee.
Parking
Downtown Knoxville has many affordable parking lots near major attractions.

Safety Tips

Road Safety
Stay alert for heavy truck traffic on I-40.
Vehicle Check
Check your tire pressure before the long drive.
Emergency
Keep a charged phone and a portable power bank in your car.
Visibility
Use your headlights during heavy rain, which is common in the region.