The drive from Lexington, Virginia to Columbus, Ohio is approximately 350 miles. The most direct route takes you west through West Virginia via I-64 W and US-35 N. This journey takes about 6 hours of driving time. You will cross the Appalachian Mountains and enter the flat plains of Ohio. It is a straightforward drive that is manageable in a single day.
Total Distance: 560 km driving distance; 450 km straight-line air distance.
US-35 has several small towns; watch your speed.
Spring and Fall for comfortable driving weather.